Issue 5, 2013

Recognition of glycosaminoglycan chemical patterns using an unbiased sensor array

Abstract

A sensor array composed of eight functionalized gold nanoparticles and a fluorescent polymer was utilized to identify 11 glycosaminoglycans (GAGs) by their chemical signatures. Particle ligand structure was key in differentiating analytes, with aromatic and specific sugar functionalities recognizing GAG structural parameters including sulfonation, acetylation, epimeric structure, size, and charge.

Graphical abstract: Recognition of glycosaminoglycan chemical patterns using an unbiased sensor array

Supplementary files

Article information

Article type
Edge Article
Submitted
19 Dec 2012
Accepted
01 Mar 2013
First published
01 Mar 2013

Chem. Sci., 2013,4, 2076-2080

Recognition of glycosaminoglycan chemical patterns using an unbiased sensor array

S. G. Elci, D. F. Moyano, S. Rana, G. Y. Tonga, R. L. Phillips, U. H. F. Bunz and V. M. Rotello, Chem. Sci., 2013, 4, 2076 DOI: 10.1039/C3SC22279A

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