Issue 6, 2013
From the journal:

Chemical Science

Redox of ferrocene controlled asymmetric dehydrogenative Heck reactionviapalladium-catalyzed dual C–H bond activation†

Chao Pi,a   Ying Li,a   Xiuling Cui,*ab   Hao Zhang,a   Yanbing Hana  and  Yangjie Wu*a  

* Corresponding authors

a Henan Key Laboratory of Chemical Biology and Organic Chemistry, Key Laboratory of Applied Chemistry of Henan Universities, Department of Chemistry, Zhengzhou University, Da Xue Rd. 75, Zhengzhou 450052, China
E-mail: cuixl@zzu.edu.cn, wyj@zzu.edu.cn
Fax: +86-371-67767753

b Engineering Research Center of Molecular Medicine of Chinese Education Ministry, Xiamen Key Laboratory of Ocean and Gene Drugs, Institute of Molecular Medicine of Huaqiao University, Xiamen, Fujian, China

Abstract

A novel strategy of dehydrogenative Heck reaction controlled by redox process of ferrocene has been developed. Commercially available chiral amino acid as ligand realized asymmetric dehydrogenative Heck reaction, leading to planar-chiral ferrocene derivatives with excellent enantioselectivity and in good to excellent yields (up to 99% ee and 98% yield).

Graphical abstract: Redox of ferrocene controlled asymmetric dehydrogenative Heck reaction via palladium-catalyzed dual C–H bond activation

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Article information

DOI
https://doi.org/10.1039/C3SC50577D
Article type
Edge Article
Submitted
28 Feb 2013
Accepted
08 Apr 2013
First published
09 Apr 2013

Chem. Sci., 2013,4, 2675-2679

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Redox of ferrocene controlled asymmetric dehydrogenative Heck reaction via palladium-catalyzed dual C–H bond activation

C. Pi, Y. Li, X. Cui, H. Zhang, Y. Han and Y. Wu, Chem. Sci., 2013, 4, 2675 DOI: 10.1039/C3SC50577D

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