Issue 6, 2013

Copper(i)-catalyzed diastereoselective hydroxytrifluoromethylation of dienes accelerated by phosphine ligands

Abstract

A diastereoselective 1,4-hydroxytrifluoromethylation of dienes is catalyzed by copper cyanide–phosphine complexes. This reaction is significantly accelerated by bulky monodentate phosphines, and the discovery enables expedient access to a variety of CF3-containing allylic alcohol derivatives.

Graphical abstract: Copper(i)-catalyzed diastereoselective hydroxytrifluoromethylation of dienes accelerated by phosphine ligands

Supplementary files

Article information

Article type
Edge Article
Submitted
28 Feb 2013
Accepted
19 Mar 2013
First published
20 Mar 2013

Chem. Sci., 2013,4, 2478-2482

Copper(I)-catalyzed diastereoselective hydroxytrifluoromethylation of dienes accelerated by phosphine ligands

D. Lu, C. Zhu and H. Xu, Chem. Sci., 2013, 4, 2478 DOI: 10.1039/C3SC50582K

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