Issue 7, 2013

Discovery of an iridacycle catalyst with improved reactivity and enantioselectivity in the hydrogenation of dialkyl ketimines

Abstract

Catalytically active iridacycles are formed by cyclometalation of acetophenone imines with Ir–PHOX complexes under hydrogen atmosphere. These complexes show unusually high reactivity and enantioselectivity in the hydrogenation of alkyl methyl ketimines. The structure of the cyclometalated imine has a strong effect on the conversion and enantiomeric excess.

Graphical abstract: Discovery of an iridacycle catalyst with improved reactivity and enantioselectivity in the hydrogenation of dialkyl ketimines

Supplementary files

Article information

Article type
Edge Article
Submitted
01 Mar 2013
Accepted
09 Apr 2013
First published
09 Apr 2013
This article is Open Access

All publication charges for this article have been paid for by the Royal Society of Chemistry
Creative Commons BY license

Chem. Sci., 2013,4, 2760-2766

Discovery of an iridacycle catalyst with improved reactivity and enantioselectivity in the hydrogenation of dialkyl ketimines

Y. Schramm, F. Barrios-Landeros and A. Pfaltz, Chem. Sci., 2013, 4, 2760 DOI: 10.1039/C3SC50587A

This article is licensed under a Creative Commons Attribution 3.0 Unported Licence. You can use material from this article in other publications without requesting further permissions from the RSC, provided that the correct acknowledgement is given.

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