Issue 10, 2013

Synthesis of a well-defined glycoconjugate vaccine by a tyrosine-selective conjugation strategy

Abstract

An anti-candidiasis glycoconjugate vaccine was prepared via a tyrosine-selective alkynylation and a click chemistry mediated glycoconjugation sequence. It features a well-defined glycan, protein carrier, and connectivity. The construct, although with significantly lower carbohydrate loading and a shorter β-(1,3) glucan chain than the well-established anti-candidiasis vaccine derived from the random conjugation of laminarin at lysines, elicited a comparable level of specific IgG antibodies.

Graphical abstract: Synthesis of a well-defined glycoconjugate vaccine by a tyrosine-selective conjugation strategy

Supplementary files

Article information

Article type
Edge Article
Submitted
18 Jun 2013
Accepted
28 Jun 2013
First published
01 Jul 2013
This article is Open Access

All publication charges for this article have been paid for by the Royal Society of Chemistry
Creative Commons BY license

Chem. Sci., 2013,4, 3827-3832

Synthesis of a well-defined glycoconjugate vaccine by a tyrosine-selective conjugation strategy

Q. Hu, M. Allan, R. Adamo, D. Quinn, H. Zhai, G. Wu, K. Clark, J. Zhou, S. Ortiz, B. Wang, E. Danieli, S. Crotti, M. Tontini, G. Brogioni and F. Berti, Chem. Sci., 2013, 4, 3827 DOI: 10.1039/C3SC51694F

This article is licensed under a Creative Commons Attribution 3.0 Unported Licence. You can use material from this article in other publications without requesting further permissions from the RSC, provided that the correct acknowledgement is given.

Read more about how to correctly acknowledge RSC content.

Social activity

Spotlight

Advertisements