Issue 25, 2013
From the journal:

Journal of Materials Chemistry B

Development of new drug delivery system based on ordered mesoporous carbons: characterisation and cytocompatibility studies†

Christina Karavasili,‡a   Elsa P. Amanatiadou,‡b   Lambrini Sygellou,c   Dimitra K. Giasafaki,d   Theodore A. Steriotis,d   Georgia C. Charalambopoulou,d   Ioannis S. Vizirianakisb  and  Dimitrios G. Fatouros*a  

* Corresponding authors

a Laboratory of Pharmaceutical Technology, Department of Pharmaceutical Sciences, Aristotle University of Thessaloniki, GR-54124 Thessaloniki, Greece
E-mail: dfatouro@pharm.auth.gr
Tel: +30 2310997653

b Laboratory of Pharmacology, Department of Pharmaceutical Sciences, Aristotle University of Thessaloniki, GR-54124 Thessaloniki, Greece

c Foundation for Research and Technology, Hellas-Institute of Chemical Engineering Sciences, FORTH/ICE-HT, P.O. Box 1414, GR-26504 Patras, Greece

d National Center for Scientific Research “Demokritos”, Agia Paraskevi Attikis 15341, Greece

Abstract

Ordered mesoporous carbons that encapsulate the poorly soluble compounds ibuprofen and indomethacin were systematically studied by means of X-ray diffraction (XRD), differential scanning calorimetry (DSC) and X-ray photon electron spectroscopy (XPS). The results showed marked differences in the release profiles of the two drug molecules in simulated gastric fluids. In vitro toxicity profiles appear to be compatible with potential therapeutic applications bringing them to the forefront as carriers of poorly water soluble drugs.

Graphical abstract: Development of new drug delivery system based on ordered mesoporous carbons: characterisation and cytocompatibility studies

About
Cited by
Related
Download options Please wait...

Supplementary files

Article information

DOI
https://doi.org/10.1039/C3TB20304B
Article type
Paper
Submitted
05 Mar 2013
Accepted
29 Apr 2013
First published
23 May 2013

J. Mater. Chem. B, 2013,1, 3167-3174

Permissions

Request permissions

Development of new drug delivery system based on ordered mesoporous carbons: characterisation and cytocompatibility studies

C. Karavasili, E. P. Amanatiadou, L. Sygellou, D. K. Giasafaki, T. A. Steriotis, G. C. Charalambopoulou, I. S. Vizirianakis and D. G. Fatouros, J. Mater. Chem. B, 2013, 1, 3167 DOI: 10.1039/C3TB20304B

To request permission to reproduce material from this article, please go to the Copyright Clearance Center request page.

If you are an author contributing to an RSC publication, you do not need to request permission provided correct acknowledgement is given.

If you are the author of this article, you do not need to request permission to reproduce figures and diagrams provided correct acknowledgement is given. If you want to reproduce the whole article in a third-party publication (excluding your thesis/dissertation for which permission is not required) please go to the Copyright Clearance Center request page.

Read more about how to correctly acknowledge RSC content.

Social activity

Spotlight

Advertisements