Issue 41, 2013
From the journal:

Journal of Materials Chemistry B

Prodrugs forming multifunctional supramolecular hydrogels for dual cancer drug delivery†

Wei Ha,a   Jing Yu,a   Xin-yue Song,a   Zhi-jun Zhang,b   Ying-qian Liub  and  Yan-ping Shi*a  

* Corresponding authors

a Key Laboratory of Chemistry of Northwestern Plant Resources of CAS, Key Laboratory for Natural Medicine of Gansu Province, Lanzhou Institute of Chemical Physics, Chinese Academy of Sciences, Lanzhou, P. R. China
E-mail: shiyp@licp.cas.cn
Fax: +86-931-4968094
Tel: +86-931-4968028

b School of Pharmacy, Lanzhou University, Lanzhou, P. R. China

Abstract

Here we report a multifunctional supramolecular hydrogel based on host–guest inclusion for loading two different anticancer drugs with different controlled release profiles. The resulting hydrogels are characterized by possessing dual phase drug release behavior and producing a dose and cell type dependent synergetic cytotoxicity to cancer cells, which can be used for cancer combination therapy.

Graphical abstract: Prodrugs forming multifunctional supramolecular hydrogels for dual cancer drug delivery

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Article information

DOI
https://doi.org/10.1039/C3TB20956C
Article type
Communication
Submitted
09 Jul 2013
Accepted
22 Aug 2013
First published
22 Aug 2013

J. Mater. Chem. B, 2013,1, 5532-5538

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Prodrugs forming multifunctional supramolecular hydrogels for dual cancer drug delivery

W. Ha, J. Yu, X. Song, Z. Zhang, Y. Liu and Y. Shi, J. Mater. Chem. B, 2013, 1, 5532 DOI: 10.1039/C3TB20956C

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