Doxorubicin loading on graphene oxide, iron oxide and gold nanoparticle hybrid

Abstract

We report the facile and non-covalent construction of a graphene oxide-based functional hybrid material with gold and fluorescently labeled superparamagnetic iron oxide nanoparticles [GO–MN_cy5.5–AuNP]. The obtained [GO–MN_cy5.5–AuNP] hybrid exhibits the physical properties of each component. The relaxivity of the magnetic nanoparticles was improved, cy5.5 fluorescence was completely quenched and the surface plasmon peak of the gold nanoparticles at 520 nm was observed in the hybrid complex. The hybrid exhibits an ultra-high doxorubicin loading capacity of 6.05 mg mg⁻¹ at 0.32 mg ml⁻¹ drug concentration. This material could serve as a promising platform for theranostics, due to its contrast agent composition and anticancer drug loading capacity.