Light-triggered carbon monoxide delivery with Al-MCM-41-based nanoparticles bearing a designed manganese carbonyl complex

Abstract

A photoactive manganese carbonyl complex namely, fac-[Mn(pqa)(CO)₃]ClO₄ (abbreviated as {Mn–CO}, pqa = (2-pyridylmethyl)(2-quinolylmethyl)amine) has been incorporated in the pores of 60 nm mesoporous Al-MCM-41 nanoparticles. Strong electrostatic interactions with the negatively charged walls of the aluminosilicate host entrap the cationic carbonyl complex in the resulting material {Mn–CO}@Al-MCM-41 which has been characterized by various physical techniques and chemical analysis. The sample morphology and microstructure of the material have been established by scanning electron microscopy (SEM) and transmission electron microscopy (TEM). Results of powder X-ray diffraction (PXRD) data and the SEM-EDX elemental maps of Si, O, Al and Mn confirm that the carbonyl complex is within the pores of the nanoparticles. The 2% manganese content of {Mn–CO}@Al-MCM-41, determined by acid digestion followed by inductively coupled plasma-optical emission spectroscopy (ICP-OES), indicates efficient loading of the carbonyl complex in the nanoparticles. In biological buffer solutions, less than 2% leaching of {Mn–CO} from the nanoparticles was noted within a period of 24 h. When exposed to a broadband visible light source (λ > 350 nm), {Mn–CO}@Al-MCM-41 rapidly releases CO, as confirmed by the reduced myoglobin assay. The utility of light-induced CO delivery by {Mn–CO}@Al-MCM-41 has been established by its capacity to relax rat aorta muscle rings in tissue bath experiments.