Issue 25, 2014

Controllable drug release and effective intracellular accumulation highlighted by anisotropic biodegradable PLGE nanoparticles

Abstract

Control of the stretching or compressing ratio of spherical nanoparticles (NPs) leads to a dramatic change in the shape and size of particles based on amphiphilic biodegradable poly(lactide-co-glycolide-b-ethylene glycol-b-lactide-co-glycolide) (PLGE) triblock copolymers. Drug release, endocytosis and intracellular accumulation tests on these anisotropic PLGE NPs show significantly enhanced properties in comparison with spherical NPs, indicating they are good candidates for drug delivery.

Graphical abstract: Controllable drug release and effective intracellular accumulation highlighted by anisotropic biodegradable PLGE nanoparticles

Supplementary files

Article information

Article type
Communication
Submitted
05 Dec 2013
Accepted
26 Mar 2014
First published
27 Mar 2014

J. Mater. Chem. B, 2014,2, 3911-3914

Author version available

Controllable drug release and effective intracellular accumulation highlighted by anisotropic biodegradable PLGE nanoparticles

J. Fan, Y. Song, H. Li, J. Jia, X. Guo and L. Jiang, J. Mater. Chem. B, 2014, 2, 3911 DOI: 10.1039/C3TB21726D

To request permission to reproduce material from this article, please go to the Copyright Clearance Center request page.

If you are an author contributing to an RSC publication, you do not need to request permission provided correct acknowledgement is given.

If you are the author of this article, you do not need to request permission to reproduce figures and diagrams provided correct acknowledgement is given. If you want to reproduce the whole article in a third-party publication (excluding your thesis/dissertation for which permission is not required) please go to the Copyright Clearance Center request page.

Read more about how to correctly acknowledge RSC content.

Social activity

Spotlight

Advertisements