Organelle-selective fluorescent Cu2+ ion probes: revealing the endoplasmic reticulum as a reservoir for Cu-overloading

Yun Hak Lee; Nayoung Park; Young Bin Park; Yu Jeong Hwang; Chulhun Kang; Jong Seung Kim

doi:10.1039/C4CC00091A

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Organelle-selective fluorescent Cu²⁺ ion probes: revealing the endoplasmic reticulum as a reservoir for Cu-overloading†

Yun Hak Lee,^a Nayoung Park,^a Young Bin Park,^b Yu Jeong Hwang,^b Chulhun Kang*^b and Jong Seung Kim*^a

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* Corresponding authors

^a Department of Chemistry, Korea University, Seoul 136-701, Korea
E-mail: jongskim@korea.ac.kr

^b The East-West Medical Science, Kyung Hee University, Yongin 446-701, Korea
E-mail: kangch@khu.ac.kr

Abstract

Two novel Cu²⁺ sensors, 1 and 2, bearing naphthalimide and a DPA moiety were synthesized to study copper accumulation in organelles by selective Cu²⁺ sensing. The ER-selective Cu²⁺ sensor 1 that we developed serves as a valuable tool for understanding the subcellular compartmentalization and roles of copper ions in physiology and pathophysiology.

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Article information

DOI: https://doi.org/10.1039/C4CC00091A
Article type: Communication
Submitted: 06 Jan 2014
Accepted: 29 Jan 2014
First published: 30 Jan 2014

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Chem. Commun., 2014,50, 3197-3200

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Organelle-selective fluorescent Cu²⁺ ion probes: revealing the endoplasmic reticulum as a reservoir for Cu-overloading

Y. H. Lee, N. Park, Y. B. Park, Y. J. Hwang, C. Kang and J. S. Kim, Chem. Commun., 2014, 50, 3197 DOI: 10.1039/C4CC00091A

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