Issue 28, 2014

PdCl2 catalyzed efficient assembly of organic azides, CO, and alcohols under mild conditions: a direct approach to synthesize carbamates

Abstract

A simple and readily available PdCl2 catalyzed carbamate synthesis method via isocyanate generation and application in situ has been developed. This chemistry provides an efficient and practical approach to synthesize carbamates from simple organic azides, CO atmosphere and alcohols. The broad scope, mild and neutral conditions, and only N2 as the byproduct make this transformation very useful. Moreover, simple examples of modification of bioactive molecules and construction of macrocycles were achieved through this protocol.

Graphical abstract: PdCl2 catalyzed efficient assembly of organic azides, CO, and alcohols under mild conditions: a direct approach to synthesize carbamates

Supplementary files

Article information

Article type
Communication
Submitted
21 Jan 2014
Accepted
11 Feb 2014
First published
12 Feb 2014

Chem. Commun., 2014,50, 3706-3709

PdCl2 catalyzed efficient assembly of organic azides, CO, and alcohols under mild conditions: a direct approach to synthesize carbamates

L. Ren and N. Jiao, Chem. Commun., 2014, 50, 3706 DOI: 10.1039/C4CC00538D

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