Issue 38, 2014

Applying a multitarget rational drug design strategy: the first set of modulators with potent and balanced activity toward dopamine D3 receptor and fatty acid amide hydrolase

Abstract

Combining computer-assisted drug design and synthetic efforts, we generated compounds with potent and balanced activities toward both D3 dopamine receptor and fatty acid amide hydrolase (FAAH) enzyme. By concurrently modulating these targets, our compounds hold great potential toward exerting a disease-modifying effect on nicotine addiction and other forms of compulsive behavior.

Graphical abstract: Applying a multitarget rational drug design strategy: the first set of modulators with potent and balanced activity toward dopamine D3 receptor and fatty acid amide hydrolase

Supplementary files

Article information

Article type
Communication
Submitted
05 Feb 2014
Accepted
24 Mar 2014
First published
25 Mar 2014

Chem. Commun., 2014,50, 4904-4907

Author version available

Applying a multitarget rational drug design strategy: the first set of modulators with potent and balanced activity toward dopamine D3 receptor and fatty acid amide hydrolase

A. De Simone, G. F. Ruda, C. Albani, G. Tarozzo, T. Bandiera, D. Piomelli, A. Cavalli and G. Bottegoni, Chem. Commun., 2014, 50, 4904 DOI: 10.1039/C4CC00967C

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