A bio-orthogonal click-chemistry procedure was developed to allow the in cell interactome profiling of scalaradial, an anti-inflammatory marine natural product. The results were validated through the application of the classical in vitro chemical proteomics and several bio-physical methods; peroxiredoxins, 14-3-3 isoforms and proteasomes were recognized as main scalaradial targets.
C. Cassiano, L. Margarucci, R. Esposito, R. Riccio, A. Tosco, A. Casapullo and M. C. Monti, Chem. Commun., 2014, 50, 6043 DOI: 10.1039/C4CC00989D
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