Issue 49, 2014

The rational design of a highly sensitive and selective fluorogenic probe for detecting nitric oxide

Abstract

A rationally designed small-molecule fluorogenic probe for nitric oxide (NO) detection based on a new switching mechanism has been developed. Attaching a NO-responsive dihydropyridine pendant group to a fluorophore led to a probe that displays a very high sensitivity to NO concentrations down to the low nM range and a very high specificity to NO while being insensitive to other oxidative oxygen/nitrogen species that often interfere with the sensing of NO.

Graphical abstract: The rational design of a highly sensitive and selective fluorogenic probe for detecting nitric oxide

Supplementary files

Article information

Article type
Communication
Submitted
12 Feb 2014
Accepted
19 Mar 2014
First published
19 Mar 2014

Chem. Commun., 2014,50, 6475-6478

Author version available

The rational design of a highly sensitive and selective fluorogenic probe for detecting nitric oxide

S. Ma, D. Fang, B. Ning, M. Li, L. He and B. Gong, Chem. Commun., 2014, 50, 6475 DOI: 10.1039/C4CC01142B

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