Issue 57, 2014
From the journal:

Chemical Communications

Ultrasensitive detection of ATP based on ATP regeneration amplification and its application in cell homogenate and human serum†

Yingshu Guo,*a   Xiaofeng Sun,b   Guangxu Yangb  and  Jia liub  

* Corresponding authors

a School of Chemistry and Chemical Engineering, Linyi University, Linyi 276005, China
E-mail: yingshug@126.com
Tel: +86-539-8766867

b Key Laboratory of Biochemical Analysis, Ministry of Education, College of Chemistry and Molecular Engineering, Qingdao University of Science and Technology, Qingdao 266042, China

Abstract

A conformation-switching aptamer molecule that could be circularized without ligation DNA was designed. Pyrophosphate (PPi) was converted to ATP, resulting in higher signals for ATP detection. Meanwhile, the method has significant implications for real applications.

Graphical abstract: Ultrasensitive detection of ATP based on ATP regeneration amplification and its application in cell homogenate and human serum

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Article information

DOI
https://doi.org/10.1039/C4CC01458H
Article type
Communication
Submitted
25 Feb 2014
Accepted
22 Apr 2014
First published
23 Apr 2014

Chem. Commun., 2014,50, 7659-7662

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Ultrasensitive detection of ATP based on ATP regeneration amplification and its application in cell homogenate and human serum

Y. Guo, X. Sun, G. Yang and J. liu, Chem. Commun., 2014, 50, 7659 DOI: 10.1039/C4CC01458H

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