Issue 51, 2014

Multivalent comb-type aptamer–siRNA conjugates for efficient and selective intracellular delivery

Abstract

In this study, a simple and efficient strategy for selective intracellular delivery of RNA therapeutics into target cancer cells was designed using direct complementary base pairing between chemically conjugated multimeric antisense strands and aptamer-incorporating sense strands.

Graphical abstract: Multivalent comb-type aptamer–siRNA conjugates for efficient and selective intracellular delivery

Supplementary files

Article information

Article type
Communication
Submitted
04 Mar 2014
Accepted
07 May 2014
First published
08 May 2014

Chem. Commun., 2014,50, 6765-6767

Multivalent comb-type aptamer–siRNA conjugates for efficient and selective intracellular delivery

H. Yoo, H. Jung, S. A. Kim and H. Mok, Chem. Commun., 2014, 50, 6765 DOI: 10.1039/C4CC01620C

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