Issue 43, 2014

Detection of Aβ plaques in mouse brain by using a disaggregation-induced fluorescence-enhancing probe

Abstract

We herein report a fluorescence probe 1 capable of detecting water-soluble oligomeric Aβ aggregates and Aβ fibrils. Upon injection into Aβ42-challenged mouse brains, probe 1 shows increased fluorescence intensity, indicating its facile binding to extracellular Aβ fibrils in brain tissues.

Graphical abstract: Detection of Aβ plaques in mouse brain by using a disaggregation-induced fluorescence-enhancing probe

Supplementary files

Article information

Article type
Communication
Submitted
18 Mar 2014
Accepted
05 Apr 2014
First published
07 Apr 2014

Chem. Commun., 2014,50, 5741-5744

Detection of Aβ plaques in mouse brain by using a disaggregation-induced fluorescence-enhancing probe

Y. O. Lee, J. Shin, C. Yi, Y. H. Lee, N. Sohn, C. Kang and J. S. Kim, Chem. Commun., 2014, 50, 5741 DOI: 10.1039/C4CC02011A

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