Direct condensation of functionalized sp3 carbons with formanilides for enamine synthesis using an in situ generated HMDS amide catalyst

Hiroshi Taneda; Kiyofumi Inamoto; Yoshinori Kondo

doi:10.1039/C4CC02228A

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Direct condensation of functionalized sp³ carbons with formanilides for enamine synthesis using an in situ generated HMDS amide catalyst†

Hiroshi Taneda,^a Kiyofumi Inamoto^a and Yoshinori Kondo*^a

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* Corresponding authors

^a Graduate School of Pharmaceutical Sciences, Tohoku University, 6-3 Aoba, Aramaki, Aoba-ku, Sendai 980-8578, Japan
E-mail: ykondo@m.tohoku.ac.jp
Fax: +81-22-795-6804
Tel: +81-22-795-6804

Abstract

The efficient synthesis of functionalized enamines including β-enaminoesters was effectively accomplished by the direct condensation of functionalized sp³ carbanions such as acetates with formamides using in situ generated HMDS base from catalytic cesium fluoride and stoichiometric tristrimethylsilylamine.

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Article information

DOI: https://doi.org/10.1039/C4CC02228A
Article type: Communication
Submitted: 26 Mar 2014
Accepted: 23 Apr 2014
First published: 02 May 2014

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Chem. Commun., 2014,50, 6523-6525

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Direct condensation of functionalized sp³ carbons with formanilides for enamine synthesis using an in situ generated HMDS amide catalyst

H. Taneda, K. Inamoto and Y. Kondo, Chem. Commun., 2014, 50, 6523 DOI: 10.1039/C4CC02228A

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