Issue 57, 2014

Copper-mediated pyrazole synthesis from 2,3-allenoates or 2-alkynoates, amines and nitriles

Abstract

An efficient copper-mediated three-component reaction of 2,3-allenoates or 2-alkynoates, amines, and nitriles affording fully substituted pyrazoles with a very nice diversity has been developed. A tandem conjugate addition, 1,2-addition, and N–N bond formation mechanism has been proposed for this diverse synthesis of pyrazoles based on mechanistic studies.

Graphical abstract: Copper-mediated pyrazole synthesis from 2,3-allenoates or 2-alkynoates, amines and nitriles

Supplementary files

Article information

Article type
Communication
Submitted
24 Apr 2014
Accepted
21 May 2014
First published
22 May 2014

Chem. Commun., 2014,50, 7677-7679

Copper-mediated pyrazole synthesis from 2,3-allenoates or 2-alkynoates, amines and nitriles

B. Chen, C. Zhu, Y. Tang and S. Ma, Chem. Commun., 2014, 50, 7677 DOI: 10.1039/C4CC02856B

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