Issue 57, 2014

A biotin-guided fluorescent-peptide drug delivery system for cancer treatment

Abstract

Herein, we present a fluorescent-peptide drug delivery system composed of biotin–naphthalimide–HJ inhibitor peptide2, prodrug 1. Treatment of 1 to biotin receptor-positive HepG2 cells, which are resistant to high concentrations of the HJ inhibitor peptide2, decreased cell viability and increased intracellular fluorescence.

Graphical abstract: A biotin-guided fluorescent-peptide drug delivery system for cancer treatment

Supplementary files

Article information

Article type
Communication
Submitted
18 Apr 2014
Accepted
14 May 2014
First published
15 May 2014

Chem. Commun., 2014,50, 7690-7693

A biotin-guided fluorescent-peptide drug delivery system for cancer treatment

T. Kim, H. M. Jeon, H. T. Le, T. W. Kim, C. Kang and J. S. Kim, Chem. Commun., 2014, 50, 7690 DOI: 10.1039/C4CC02878C

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