Issue 66, 2014

Efficient metal-free hydrosilylation of tertiary, secondary and primary amides to amines

Abstract

Hydrosilylation of secondary and tertiary amides to amines is described using catalytic amounts of B(C6F5)3. The organic catalyst enables the reduction of amides with cost-efficient, non-toxic and air stable PMHS and TMDS hydrosilanes. The methodology was successfully extended to the more challenging reduction of primary amides.

Graphical abstract: Efficient metal-free hydrosilylation of tertiary, secondary and primary amides to amines

Supplementary files

Article information

Article type
Communication
Submitted
18 Apr 2014
Accepted
24 Jun 2014
First published
27 Jun 2014

Chem. Commun., 2014,50, 9349-9352

Author version available

Efficient metal-free hydrosilylation of tertiary, secondary and primary amides to amines

E. Blondiaux and T. Cantat, Chem. Commun., 2014, 50, 9349 DOI: 10.1039/C4CC02894E

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