Issue 76, 2014

Identification of bromophenol thiohydantoin as an inhibitor of DisA, a c-di-AMP synthase, from a 1000 compound library, using the coralyne assay

Abstract

c-di-AMP is an important bacterial second messenger found in Gram-positive and mycobacteria. c-di-AMP regulates myriads of processes in bacteria as well as immune response in higher organisms so interest in small molecules that would attenuate the activity of c-di-AMP metabolism enzymes is high. Herein, we report the first small molecule inhibitor of a c-di-AMP synthase, DisA, using a coralyne-based assay.

Graphical abstract: Identification of bromophenol thiohydantoin as an inhibitor of DisA, a c-di-AMP synthase, from a 1000 compound library, using the coralyne assay

Supplementary files

Article information

Article type
Communication
Submitted
19 Apr 2014
Accepted
05 Aug 2014
First published
06 Aug 2014
This article is Open Access
Creative Commons BY-NC license

Chem. Commun., 2014,50, 11234-11237

Author version available

Identification of bromophenol thiohydantoin as an inhibitor of DisA, a c-di-AMP synthase, from a 1000 compound library, using the coralyne assay

Y. Zheng, J. Zhou, D. A. Sayre and H. O. Sintim, Chem. Commun., 2014, 50, 11234 DOI: 10.1039/C4CC02916J

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