Issue 85, 2014
From the journal:

Chemical Communications

A novel Affibody bioconjugate for dual-modality imaging of ovarian cancer†

Yihong Wang,ab   Zheng Miao,b   Gang Ren,b   Yingding Xub  and  Zhen Cheng*b  

* Corresponding authors

a Department of Chemistry and Chemical Engineering, Southeast University, Nanjing, Jiangsu, P. R. China

b Molecular Imaging Program at Stanford (MIPS), Bio-X Program, Department of Radiology, Stanford University, California, USA
E-mail: zcheng@stanford.edu
Fax: +1 650-736-7925
Tel: +1 650-723-7866

Abstract

An Affibody based dual imaging probe (PET and optical imaging) has been successfully developed. Dendrimer PAMAM G0 was used as a platform to assemble an NIRF dye, a metal chelator, and Affibody for dual modality imaging of ovarian cancer. Excellent tumor imaging quality was achieved in both modalities in the living tumor mice models.

Graphical abstract: A novel Affibody bioconjugate for dual-modality imaging of ovarian cancer

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Article information

DOI
https://doi.org/10.1039/C4CC03454F
Article type
Communication
Submitted
07 May 2014
Accepted
05 Jun 2014
First published
05 Jun 2014

Chem. Commun., 2014,50, 12832-12835

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A novel Affibody bioconjugate for dual-modality imaging of ovarian cancer

Y. Wang, Z. Miao, G. Ren, Y. Xu and Z. Cheng, Chem. Commun., 2014, 50, 12832 DOI: 10.1039/C4CC03454F

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