Issue 67, 2014
From the journal:

Chemical Communications

Photodegradation of amyloid β and reduction of its cytotoxicity to PC12 cells using porphyrin derivatives†

Ayumi Hirabayashi,a   Yutaka Shindo,b   Kotaro Oka,b   Daisuke Takahashia  and  Kazunobu Toshima*a  

* Corresponding authors

a Department of Applied Chemistry, Faculty of Science and Technology, Keio University, 3-14-1 Hiyoshi, Kohoku-ku, Yokohama 223-8522, Japan
E-mail: toshima@applc.keio.ac.jp
Fax: +81 45-566-1576

b Department of Bioscience and Informatics, Faculty of Science and Technology, Keio University, 3-14-1 Hiyoshi, Kohoku-ku, Yokohama 223-8522, Japan

Abstract

A purpose-designed porphyrin–peptide hybrid effectively degraded amyloid β monomer and oligomers associated with Alzheimer's disease. Degradation was achieved using light irradiation in the absence of any additives and under neutral conditions. Moreover, the hybrid effectively neutralized the cytotoxicity of amyloid β in PC12 cells upon photoirradiation.

Graphical abstract: Photodegradation of amyloid β and reduction of its cytotoxicity to PC12 cells using porphyrin derivatives

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Article information

DOI
https://doi.org/10.1039/C4CC03791J
Article type
Communication
Submitted
19 May 2014
Accepted
04 Jul 2014
First published
07 Jul 2014

Chem. Commun., 2014,50, 9543-9546

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Photodegradation of amyloid β and reduction of its cytotoxicity to PC12 cells using porphyrin derivatives

A. Hirabayashi, Y. Shindo, K. Oka, D. Takahashi and K. Toshima, Chem. Commun., 2014, 50, 9543 DOI: 10.1039/C4CC03791J

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