Issue 89, 2014
From the journal:

Chemical Communications

Copper-mediated aromatic amination reaction and its application to the total synthesis of natural products

Kentaro Okano,a   Hidetoshi Tokuyama*a  and  Tohru Fukuyama*b  

* Corresponding authors

a Graduate School of Pharmaceutical Sciences, Tohoku University, Aoba, Aramaki, Aoba-ku, Sendai 980-8578, Japan
E-mail: tokuyama@mail.pharm.tohoku.ac.jp
Fax: +81-22-795-6877
Tel: +81-22-795-6887

b Graduate School of Pharmaceutical Sciences, Nagoya University, Furo-cho, Chikusa-ku, Nagoya 464-8601, Japan
E-mail: fukuyama@ps.nagoya-u.ac.jp
Fax: +81-52-747-6817
Tel: +81-52-747-6799

Abstract

Herein, we review copper-mediated aromatic amination reactions including the classical Ullmann coupling and the recently developed mild aryl amination with an effective ligand as well as the C–H amination reaction. Several applications of intramolecular aryl amination to the syntheses of natural products demonstrate the general applicability of the reaction.

Graphical abstract: Copper-mediated aromatic amination reaction and its application to the total synthesis of natural products

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Article information

DOI
https://doi.org/10.1039/C4CC03895A
Article type
Feature Article
Submitted
21 May 2014
Accepted
03 Jul 2014
First published
03 Jul 2014

Chem. Commun., 2014,50, 13650-13663

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Copper-mediated aromatic amination reaction and its application to the total synthesis of natural products

K. Okano, H. Tokuyama and T. Fukuyama, Chem. Commun., 2014, 50, 13650 DOI: 10.1039/C4CC03895A

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