Issue 79, 2014

Promising two-photon probes for in vivo detection of β amyloid deposits

Abstract

Based on electronic structure calculations we propose that particular small-sized organic molecules – donor–acceptor substituted phenyl polymethines – can be used as two-photon diagnostic probes for non-invasive imaging of amyloid oligomers and fibrils, which are often referred to as the “early signatures” of Alzheimer's disease.

Graphical abstract: Promising two-photon probes for in vivo detection of β amyloid deposits

Supplementary files

Article information

Article type
Communication
Submitted
21 May 2014
Accepted
07 Aug 2014
First published
07 Aug 2014

Chem. Commun., 2014,50, 11694-11697

Author version available

Promising two-photon probes for in vivo detection of β amyloid deposits

N. A. Murugan, R. Zaleśny, J. Kongsted, A. Nordberg and H. Ågren, Chem. Commun., 2014, 50, 11694 DOI: 10.1039/C4CC03897E

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