Issue 68, 2014

Metal-free oxidative direct C(sp3)–H bond functionalization of ethers with α,α-diaryl allylic alcohols

Abstract

A metal-free method for direct C(sp3)–H bond functionalization of simple ethers with α,α-diaryl allylic alcohols is described. The established protocol provides facile access to α-aryl-β-oxyalkylated carbonyl ketones via radical addition and a 1,2-aryl migration cascade process. An application of the product has been demonstrated in the synthesis of a serotonin antagonist.

Graphical abstract: Metal-free oxidative direct C(sp3)–H bond functionalization of ethers with α,α-diaryl allylic alcohols

Supplementary files

Article information

Article type
Communication
Submitted
04 Jun 2014
Accepted
26 Jun 2014
First published
27 Jun 2014

Chem. Commun., 2014,50, 9718-9721

Metal-free oxidative direct C(sp3)–H bond functionalization of ethers with α,α-diaryl allylic alcohols

X. Chu, H. Meng, Y. Zi, X. Xu and S. Ji, Chem. Commun., 2014, 50, 9718 DOI: 10.1039/C4CC04282D

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