Issue 87, 2014

Design of novel chiral N,N,O-tridentate phenanthroline ligands and their application to enantioselective addition of organozinc reagents to aldehydes

Abstract

The novel N,N,O-tridentate phenanthroline ligand (BinThro) bearing an axially chiral binaphthyl backbone prepared from BINOL was found to be an effective chiral catalyst for enantioselective addition of diethylzinc to aromatic aldehydes with high enantioselectivity (up to 95% ee).

Graphical abstract: Design of novel chiral N,N,O-tridentate phenanthroline ligands and their application to enantioselective addition of organozinc reagents to aldehydes

Supplementary files

Article information

Article type
Communication
Submitted
01 Jul 2014
Accepted
24 Jul 2014
First published
25 Jul 2014

Chem. Commun., 2014,50, 13224-13227

Author version available

Design of novel chiral N,N,O-tridentate phenanthroline ligands and their application to enantioselective addition of organozinc reagents to aldehydes

Y. Naganawa, T. Namba, T. Aoyama, K. Shoji and H. Nishiyama, Chem. Commun., 2014, 50, 13224 DOI: 10.1039/C4CC05020G

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