Issue 88, 2014
From the journal:

Chemical Communications

Iodine-mediated oxidative annulation for one-pot synthesis of pyrazines and quinoxalines using a multipathway coupled domino strategy†

K. K. Durga Rao Viswanadham,‡a   Muktapuram Prathap Reddy,‡a   Pochampalli Sathyanarayana,b   Owk Ravi,b   Ruchir Kantc  and  Surendar Reddy Bathula*ab  

* Corresponding authors

a Pharmaceutics Division, CSIR-Central Drug Research Institute, Lucknow-226 031, India

b Division of Natural Products Chemistry, CSIR-Indian Institute of Chemical Technology, Tarnaka, Hyderabad-500007, India
E-mail: bsreddy@iict.res.in

c Molecular and structural biology Division, CSIR-Central Drug Research Institute, Lucknow-226 031, India

Abstract

An efficient iodine-mediated oxidative annulation of aryl acetylenes–arylethenes–aromatic ketones with 1,2-diamines for the synthesis of pyrazines and regioselective synthesis of quinoxalines is presented. A multipathway coupled domino approach has been developed for the one-pot synthesis of 1,4-diazines with high functional group compatibility.

Graphical abstract: Iodine-mediated oxidative annulation for one-pot synthesis of pyrazines and quinoxalines using a multipathway coupled domino strategy

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Article information

DOI
https://doi.org/10.1039/C4CC05844E
Article type
Communication
Submitted
28 Jul 2014
Accepted
03 Sep 2014
First published
03 Sep 2014

Chem. Commun., 2014,50, 13517-13520

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Iodine-mediated oxidative annulation for one-pot synthesis of pyrazines and quinoxalines using a multipathway coupled domino strategy

K. K. D. R. Viswanadham, M. Prathap Reddy, P. Sathyanarayana, O. Ravi, R. Kant and S. R. Bathula, Chem. Commun., 2014, 50, 13517 DOI: 10.1039/C4CC05844E

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