Issue 89, 2014

Electrophilic iodine(i) compounds induced semipinacol rearrangement via C–X bond cleavage

Abstract

Neutral electrophilic iodine(I) species proved to be efficient reagents for C–X bond cleavage of various cyclic and acyclic α-silyloxyhalides, and the induced desilylative semipinacol rearrangement provided the corresponding ketones in good yields. The reaction is operationally simple, and proceeds under mild conditions with good functional group compatibility. Mechanistic investigations, including computational studies, were also performed.

Graphical abstract: Electrophilic iodine(i) compounds induced semipinacol rearrangement via C–X bond cleavage

Supplementary files

Article information

Article type
Communication
Submitted
01 Aug 2014
Accepted
16 Sep 2014
First published
16 Sep 2014

Chem. Commun., 2014,50, 13691-13694

Author version available

Electrophilic iodine(I) compounds induced semipinacol rearrangement via C–X bond cleavage

N. Tsuji, Y. Kobayashi and Y. Takemoto, Chem. Commun., 2014, 50, 13691 DOI: 10.1039/C4CC06014H

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