Issue 100, 2014
From the journal:

Chemical Communications

Fructose-coated nanoparticles: a promising drug nanocarrier for triple-negative breast cancer therapy†

Jiacheng Zhao,ab   Krzysztof Babiuch,a   Hongxu Lu,a   Aydan Dag,ac   Michael Gottschaldt*d  and  Martina H. Stenzel*a  

* Corresponding authors

a Centre for Advanced Macromolecular Design, School of Chemistry, The University of New South Wales, Sydney, NSW 2052, Australia
E-mail: M.Stenzel@unsw.edu.au

b Centre for Advanced Macromolecular Design, School of Chemical Engineering, The University of New South Wales, Sydney, NSW 2052, Australia

c Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Bezmialem Vakif University, 34093 Fatih, Istanbul, Turkey

d Jena Center for Soft Matter (JCSM), Philosophenweg 7, and Laboratory of Organic and Macromolecular Chemistry, Friedrich Schiller University Jena, Humboldtstrasse 10, 07743 Jena, Germany
E-mail: michael.gottschaldt@uni-jena.de

Abstract

Fructose transporter GLUT5 is overexpressed in breast cancer cell lines, but not in healthy tissue. Micelles based on fructose, which were found to be low fouling, showed a high uptake by breast cancer cells (MCF-7 and MDA-MB-231 cells), but only negligible uptake by macrophages.

Graphical abstract: Fructose-coated nanoparticles: a promising drug nanocarrier for triple-negative breast cancer therapy

About
Cited by
Related
Download options Please wait...

Supplementary files

Article information

DOI
https://doi.org/10.1039/C4CC06651K
Article type
Communication
Submitted
29 Aug 2014
Accepted
16 Oct 2014
First published
16 Oct 2014

Chem. Commun., 2014,50, 15928-15931

Author version available

Download author version (PDF)

Permissions

Request permissions

Fructose-coated nanoparticles: a promising drug nanocarrier for triple-negative breast cancer therapy

J. Zhao, K. Babiuch, H. Lu, A. Dag, M. Gottschaldt and M. H. Stenzel, Chem. Commun., 2014, 50, 15928 DOI: 10.1039/C4CC06651K

To request permission to reproduce material from this article, please go to the Copyright Clearance Center request page.

If you are an author contributing to an RSC publication, you do not need to request permission provided correct acknowledgement is given.

If you are the author of this article, you do not need to request permission to reproduce figures and diagrams provided correct acknowledgement is given. If you want to reproduce the whole article in a third-party publication (excluding your thesis/dissertation for which permission is not required) please go to the Copyright Clearance Center request page.

Read more about how to correctly acknowledge RSC content.

Social activity

Spotlight

Advertisements