Issue 96, 2014

A quartz crystal microbalance method to study the terminal functionalization of glycosaminoglycans

Abstract

We demonstrate the quartz crystal microbalance as a novel method to quantify the reaction yields and stability of the terminal conjugation of chemically complex molecules. Oxime ligation is identified as a facile, broadly applicable method for the reducing-end conjugation of glycosaminoglycans that overcomes the limited stability and yield of popular hydrazone ligation.

Graphical abstract: A quartz crystal microbalance method to study the terminal functionalization of glycosaminoglycans

Supplementary files

Article information

Article type
Communication
Submitted
01 Sep 2014
Accepted
16 Oct 2014
First published
16 Oct 2014

Chem. Commun., 2014,50, 15148-15151

Author version available

A quartz crystal microbalance method to study the terminal functionalization of glycosaminoglycans

D. Thakar, E. Migliorini, L. Coche-Guerente, R. Sadir, H. Lortat-Jacob, D. Boturyn, O. Renaudet, P. Labbe and R. P. Richter, Chem. Commun., 2014, 50, 15148 DOI: 10.1039/C4CC06905F

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