Issue 89, 2014

Protein-based fluorescent metal nanoclusters for small molecular drug screening

Abstract

A facile drug screening method based on synthesis of fluorescent gold nanoclusters inside albumin proteins loaded with small molecular drugs and comparing the relative fluorescence intensities of the resultant gold nanoclusters has been developed and successfully applied for the quantitative measurement of drug–protein binding constants.

Graphical abstract: Protein-based fluorescent metal nanoclusters for small molecular drug screening

Supplementary files

Article information

Article type
Communication
Submitted
02 Sep 2014
Accepted
17 Sep 2014
First published
17 Sep 2014

Chem. Commun., 2014,50, 13805-13808

Author version available

Protein-based fluorescent metal nanoclusters for small molecular drug screening

Y. Yu, S. Y. New, J. Xie, X. Su and Y. N. Tan, Chem. Commun., 2014, 50, 13805 DOI: 10.1039/C4CC06914E

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