Issue 92, 2014
From the journal:

Chemical Communications

Direct regioselective phosphonation of heteroaryl N-oxides with H-phosphonates under metal and external oxidant free conditions†

Hui Wang,a   Xiuling Cui,*ab   Yu Pei,a   Qianqian Zhang,a   Jie Bai,a   Donghui Weia  and  Yangjie Wu*a  

* Corresponding authors

a Department of Chemistry, Henan Key Laboratory of Chemical Biology and Organic Chemistry, Key Laboratory of Applied Chemistry of Henan Universities, Zhengzhou University, Zhengzhou, P. R. China
E-mail: cuixl@zzu.edu.cn

b Xiamen Key Laboratory of Ocean and Gene Drugs, School of Biomedical Sciences and Institute of Molecular Medicine of Huaqiao University & Engineering Research Center of Molecular Medicine of Chinese Education Ministry, Fujian, Xiamen, P. R. China

Abstract

A direct C–H/P–H functionalization of heteroaryl N-oxides with H-phosphonates is described. A wide variety of heteroaryl phosphonates were obtained in up to 92% yield in a chemo- and regioselective manner, under oxidant and metal free conditions. This procedure features practicality, high efficiency, environmental friendliness and atom economy.

Graphical abstract: Direct regioselective phosphonation of heteroaryl N-oxides with H-phosphonates under metal and external oxidant free conditions

About
Cited by
Related
Download options Please wait...

Supplementary files

Article information

DOI
https://doi.org/10.1039/C4CC07060G
Article type
Communication
Submitted
07 Sep 2014
Accepted
22 Sep 2014
First published
22 Sep 2014

Chem. Commun., 2014,50, 14409-14411

Author version available

Download author version (PDF)

Permissions

Request permissions

Direct regioselective phosphonation of heteroaryl N-oxides with H-phosphonates under metal and external oxidant free conditions

H. Wang, X. Cui, Y. Pei, Q. Zhang, J. Bai, D. Wei and Y. Wu, Chem. Commun., 2014, 50, 14409 DOI: 10.1039/C4CC07060G

To request permission to reproduce material from this article, please go to the Copyright Clearance Center request page.

If you are an author contributing to an RSC publication, you do not need to request permission provided correct acknowledgement is given.

If you are the author of this article, you do not need to request permission to reproduce figures and diagrams provided correct acknowledgement is given. If you want to reproduce the whole article in a third-party publication (excluding your thesis/dissertation for which permission is not required) please go to the Copyright Clearance Center request page.

Read more about how to correctly acknowledge RSC content.

Social activity

Spotlight

Advertisements