Catalytic SNAr of unactivated aryl chlorides

James W. Walton; Jonathan M. J. Williams

doi:10.1039/C4CC07116F

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Catalytic S_NAr of unactivated aryl chlorides†

James W. Walton*^ab and Jonathan M. J. Williams^a

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* Corresponding authors

^a Department of Chemistry, University of Bath, Claverton Down, Bath, UK

^b Department of Chemistry, Durham University, South Road, Durham, UK
E-mail: james.walton@durham.ac.uk

Abstract

We present nucleophilic aromatic substitution of unsubstituted aryl chlorides via a mechanism that is catalytic in [CpRu(p-cymene)]PF₆ and involves a Ru(η⁶-arylchloride) intermediate. From the spectroscopic evidence we infer that arene exchange is the rate limiting step in this process and develop several new Ru(II) complexes that lower the activation barrier to arene exchange.

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Article information

DOI: https://doi.org/10.1039/C4CC07116F
Article type: Communication
Submitted: 09 Sep 2014
Accepted: 06 Oct 2014
First published: 06 Oct 2014
This article is Open Access

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Chem. Commun., 2015,51, 2786-2789

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Catalytic S_NAr of unactivated aryl chlorides

J. W. Walton and J. M. J. Williams, Chem. Commun., 2015, 51, 2786 DOI: 10.1039/C4CC07116F

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