Issue 95, 2014
From the journal:

Chemical Communications

A novel aggregation-induced emission based fluorescent probe for an angiotensin converting enzyme (ACE) assay and inhibitor screening†

Haibo Wang,a   Yi Huang,a   Xiaoping Zhao,b   Wan Gong,b   Yi Wang*a  and  Yiyu Chenga  

* Corresponding authors

a College of Pharmaceutical Sciences, Zhejiang University (Zijingang Campus), Hangzhou, P. R. China
E-mail: mysky@zju.edu.cn
Fax: +86-571-88208426
Tel: +86-571-88208426

b College of Preclinical Medicine, Zhejiang Chinese Medical University, Hangzhou 310053, P. R. China

Abstract

A ‘turn-on’ fluorescent probe based on aggregation-induced emission (AIE) has been developed. It exhibits excellent selectivity and sensitivity for monitoring angiotensin converting enzyme (ACE) activity both in solutions and in living cells as well as for screening ACE inhibitors in vitro.

Graphical abstract: A novel aggregation-induced emission based fluorescent probe for an angiotensin converting enzyme (ACE) assay and inhibitor screening

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Article information

DOI
https://doi.org/10.1039/C4CC07161A
Article type
Communication
Submitted
11 Sep 2014
Accepted
06 Oct 2014
First published
06 Oct 2014

Chem. Commun., 2014,50, 15075-15078

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A novel aggregation-induced emission based fluorescent probe for an angiotensin converting enzyme (ACE) assay and inhibitor screening

H. Wang, Y. Huang, X. Zhao, W. Gong, Y. Wang and Y. Cheng, Chem. Commun., 2014, 50, 15075 DOI: 10.1039/C4CC07161A

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