Identification of novel interactors of human telomeric G-quadruplex DNA

Bruno Pagano; Luigi Margarucci; Pasquale Zizza; Jussara Amato; Nunzia Iaccarino; Chiara Cassiano; Erica Salvati; Ettore Novellino; Annamaria Biroccio; Agostino Casapullo; Antonio Randazzo

doi:10.1039/C4CC07231F

Identification of novel interactors of human telomeric G-quadruplex DNA†

Bruno Pagano,

*^a Luigi Margarucci,^b Pasquale Zizza,^c Jussara Amato,^a Nunzia Iaccarino,^a Chiara Cassiano,^b Erica Salvati,^c Ettore Novellino,^a Annamaria Biroccio,^c Agostino Casapullo^b and Antonio Randazzo^a

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^a Department of Pharmacy, University of Naples “Federico II”, Via D. Montesano 49, 80131 Napoli, Italy
E-mail: bruno.pagano@unina.it

^b Department of Pharmacy, University of Salerno, Via Giovanni Paolo II 132, 84084 Fisciano, SA, Italy

^c Experimental Chemotherapy Laboratory, Regina Elena National Cancer Institute, 00158 Rome, Italy

Abstract

A chemoproteomic-driven approach was used to investigate the interaction network between human telomeric G-quadruplex DNA and nuclear proteins. We identified novel G-quadruplex binding partners, able to recognize these DNA structures at chromosome ends, suggesting a possible, and so far unknown, role of these proteins in telomere functions.

Chemical Communications

Identification of novel interactors of human telomeric G-quadruplex DNA†

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Identification of novel interactors of human telomeric G-quadruplex DNA

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