Issue 2, 2015

Out of the active site binding pocket for carbonic anhydrase inhibitors

Abstract

A structural study of the adduct which 2-benzylsulfinylbenzoic acid forms with human carbonic anhydrase II is reported, showing a binding mode completely different from any other class of carbonic anhydrase inhibitors investigated so far; this carboxylate binds in a pocket situated out of the enzyme active site.

Graphical abstract: Out of the active site binding pocket for carbonic anhydrase inhibitors

Supplementary files

Article information

Article type
Communication
Submitted
16 Sep 2014
Accepted
29 Oct 2014
First published
29 Oct 2014

Chem. Commun., 2015,51, 302-305

Author version available

Out of the active site binding pocket for carbonic anhydrase inhibitors

K. D'Ambrosio, S. Carradori, S. M. Monti, M. Buonanno, D. Secci, D. Vullo, C. T. Supuran and G. De Simone, Chem. Commun., 2015, 51, 302 DOI: 10.1039/C4CC07320G

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