Issue 13, 2015

A selenium-containing ruthenium complex as a cancer radiosensitizer, rational design and the important role of ROS-mediated signalling

Abstract

A novel selenium-containing ruthenium complex Ru(phtpy)(phenSe)Cl(ClO4) (phtpy = 4-phenyl-2,2′:6′,2′′-terpyridine, phenSe = 2-selenicimidazole[4,5-f]1,10-phenanthroline) has been synthesized and found be able to enhance radiation-induced DNA damage through superoxide overproduction, which leads to G2/M arrest and apoptosis in cancer cells by activating ROS-mediated pathways.

Graphical abstract: A selenium-containing ruthenium complex as a cancer radiosensitizer, rational design and the important role of ROS-mediated signalling

Supplementary files

Article information

Article type
Communication
Submitted
07 Oct 2014
Accepted
02 Jan 2015
First published
02 Jan 2015

Chem. Commun., 2015,51, 2637-2640

Author version available

A selenium-containing ruthenium complex as a cancer radiosensitizer, rational design and the important role of ROS-mediated signalling

Z. Deng, L. Yu, W. Cao, W. Zheng and T. Chen, Chem. Commun., 2015, 51, 2637 DOI: 10.1039/C4CC07926D

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