Issue 11, 2015

Near infrared activation of an anticancer PtIV complex by Tm-doped upconversion nanoparticles

Abstract

The PtIV complex cis,cis,trans-[Pt(NH3)2(Cl)2(O2CCH2CH2CO2H)2] is photoactivated by near infrared light (980 nm) using NaYF4:Yb3+/Tm3+@NaYF4 core–shell upconversion nanoparticles. Coupling of this cisplatin precursor with the biocompatible PEGylated phospholipid DSPE-PEG(2000)-NH2 affords a valuable approach to decorate the surface of the nanoparticles, providing novel photoactivatable nanomaterials capable of releasing PtII species upon NIR light excitation.

Graphical abstract: Near infrared activation of an anticancer PtIV complex by Tm-doped upconversion nanoparticles

Associated articles

Supplementary files

Article information

Article type
Communication
Submitted
08 Oct 2014
Accepted
08 Dec 2014
First published
11 Dec 2014

Chem. Commun., 2015,51, 2091-2094

Author version available

Near infrared activation of an anticancer PtIV complex by Tm-doped upconversion nanoparticles

E. Ruggiero, J. Hernández-Gil, J. C. Mareque-Rivas and L. Salassa, Chem. Commun., 2015, 51, 2091 DOI: 10.1039/C4CC07960D

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