Issue 5, 2015
From the journal:

Chemical Communications

Oxidative regioselective amination of chromones exposes potent inhibitors of the hedgehog signaling pathway†

Rajarshi Samanta,‡a   Rishikesh Narayan,a   Jonathan O. Bauer,b   Carsten Strohmann,b   Sonja Sieversa  and  Andrey P. Antonchick*ac  

* Corresponding authors

a Max-Planck Institute of Molecular Physiology, Abteilumg Chemische Biologie, Otto-Hahn Strasse 11, Dortmund, Germany
E-mail: andrey.antonchick@mpi-dortmund.mpg.de

b Technische Universität Dortmund, Fakultät für Chemie und Chemische Biologie, Anorganische Chemie, Otto-Hahn Strasse 6, Dortmund, Germany

c Technische Universität Dortmund, Fakultät für Chemie und Chemische Biologie, Chemische Biologie, Otto-Hahn Strasse 6, Dortmund, Germany

Abstract

A transition metal-free, oxidative, regioselective cross-coupling between non-functionalized azoles and chromones at C2-position was developed. A broad reaction scope and further transformation of products were demonstrated. The biological evaluation of products revealed a novel class of hedgehog signaling pathway inhibitors.

Graphical abstract: Oxidative regioselective amination of chromones exposes potent inhibitors of the hedgehog signaling pathway

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Article information

DOI
https://doi.org/10.1039/C4CC08376H
Article type
Communication
Submitted
23 Oct 2014
Accepted
25 Nov 2014
First published
25 Nov 2014

Chem. Commun., 2015,51, 925-928

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Oxidative regioselective amination of chromones exposes potent inhibitors of the hedgehog signaling pathway

R. Samanta, R. Narayan, J. O. Bauer, C. Strohmann, S. Sievers and A. P. Antonchick, Chem. Commun., 2015, 51, 925 DOI: 10.1039/C4CC08376H

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