Issue 5, 2015

Ni-Catalyzed α-arylation of esters and amides with phenol derivatives

Abstract

A nickel-catalyzed α-arylation of esters and amides with phenol derivatives has been accomplished. In the presence of our unique nickel catalyst, prepared in situ from Ni(cod)2, 3,4-bis(dicyclohexylphosphino)thiophene (dcypt), and K3PO4, various esters and amides undergo α-arylation with O-arylpivalates or O-arylcarbamates to afford the corresponding coupling products. The thus obtained α-aryl esters and amides are useful precursors of privileged motifs such as α-arylcarboxylic acids and β-arylamines.

Graphical abstract: Ni-Catalyzed α-arylation of esters and amides with phenol derivatives

Supplementary files

Article information

Article type
Communication
Submitted
25 Oct 2014
Accepted
20 Nov 2014
First published
21 Nov 2014
This article is Open Access
Creative Commons BY-NC license

Chem. Commun., 2015,51, 855-857

Author version available

Ni-Catalyzed α-arylation of esters and amides with phenol derivatives

E. Koch, R. Takise, A. Studer, J. Yamaguchi and K. Itami, Chem. Commun., 2015, 51, 855 DOI: 10.1039/C4CC08426H

This article is licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported Licence. You can use material from this article in other publications, without requesting further permission from the RSC, provided that the correct acknowledgement is given and it is not used for commercial purposes.

To request permission to reproduce material from this article in a commercial publication, please go to the Copyright Clearance Center request page.

If you are an author contributing to an RSC publication, you do not need to request permission provided correct acknowledgement is given.

If you are the author of this article, you do not need to request permission to reproduce figures and diagrams provided correct acknowledgement is given. If you want to reproduce the whole article in a third-party commercial publication (excluding your thesis/dissertation for which permission is not required) please go to the Copyright Clearance Center request page.

Read more about how to correctly acknowledge RSC content.

Social activity

Spotlight

Advertisements