Issue 13, 2015

A novel one-pot method for the synthesis of substituted furopyridines: iodine-mediated oxidation of enaminones by tandem metal-free cyclization

Abstract

A novel iodine-mediated oxidative tandem cyclization reaction of simple enaminones has been developed for the synthesis of substituted furopyridines through C–C/C–N/C–O bond formation in a one-pot procedure. Substituted furopyridines are obtained in moderate to good yield. In addition, I- and Br-substituted furopyridines have been successfully produced by the electrophilic substitution of N-iodo- or N-bromosuccinimide.

Graphical abstract: A novel one-pot method for the synthesis of substituted furopyridines: iodine-mediated oxidation of enaminones by tandem metal-free cyclization

Supplementary files

Article information

Article type
Communication
Submitted
07 Nov 2014
Accepted
05 Dec 2014
First published
08 Dec 2014

Chem. Commun., 2015,51, 2573-2576

Author version available

A novel one-pot method for the synthesis of substituted furopyridines: iodine-mediated oxidation of enaminones by tandem metal-free cyclization

R. Yan, X. Li, X. Yang, X. Kang, L. Xiang and G. Huang, Chem. Commun., 2015, 51, 2573 DOI: 10.1039/C4CC08834D

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