Issue 4, 2015
From the journal:

Chemical Communications

A Nile blue based infrared fluorescent probe: imaging tumors that over-express cyclooxygenase-2†

Benhua Wang,a   Jiangli Fan,*a   Xianwu Wang,b   Hao Zhu,a   Jingyun Wang,*b   Huiying Mua  and  Xiaojun Penga  

* Corresponding authors

a State Key Laboratory of Fine Chemicals, Dalian University of Technology, No. 2 Linggong Road, High-tech District, Dalian 116024, China
E-mail: fanjl@dlut.edu.cn
Fax: +86 411 84986306
Tel: +86 411 84986327

b Department School of Life Science and Biotechnology, Dalian University of Technology, No. 2 Linggong Road, Ganjingzi District, Dalian 116024, China
E-mail: wangjingyun67@dlut.edu.cn
Fax: +86 411 84706365
Tel: +86 411 84706355

Abstract

The first Golgi-localized cyclooxygenase-2 (COX-2)-specific near-infrared (NIR) fluorescent probe, Niblue-C6-IMC, able to detect cancer cells, was designed. Importantly, Niblue-C6-IMC preferentially labeled the tumors in a mouse tumor model with deep tissue penetration capacity. It may be a promising molecular tool for guiding tumor resection during surgery.

Graphical abstract: A Nile blue based infrared fluorescent probe: imaging tumors that over-express cyclooxygenase-2

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Article information

DOI
https://doi.org/10.1039/C4CC08915D
Article type
Communication
Submitted
07 Nov 2014
Accepted
19 Nov 2014
First published
19 Nov 2014

Chem. Commun., 2015,51, 792-795

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A Nile blue based infrared fluorescent probe: imaging tumors that over-express cyclooxygenase-2

B. Wang, J. Fan, X. Wang, H. Zhu, J. Wang, H. Mu and X. Peng, Chem. Commun., 2015, 51, 792 DOI: 10.1039/C4CC08915D

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