Issue 15, 2015
From the journal:

Chemical Communications

Cucurbit[8]uril templated supramolecular ring structure formation and protein assembly modulation†

Mellany Ramaekers,‡ab   Sjors P. W. Wijnands,‡ab   Joost L. J. van Dongen,ac   Luc Brunsveldab  and  Patricia Y. W. Dankers*ab  

* Corresponding authors

a Institute for Complex Molecular Systems, Eindhoven University of Technology, P.O. Box 513, 5600 MB Eindhoven, The Netherlands
E-mail: p.y.w.dankers@tue.nl

b Laboratory of Chemical Biology, Department of Biomedical Engineering, Eindhoven University of Technology, P.O. Box 513, 5600 MB Eindhoven, The Netherlands

c Laboratory of Macromolecular and Organic Chemistry, Department of Chemical Engineering, Eindhoven University of Technology, P.O. Box 513, 5600 MB Eindhoven, The Netherlands

Abstract

The interplay of Phe-Gly-Gly (FGG)-tagged proteins and bivalent FGG-tagged penta(ethylene glycol) as guest molecules with cucurbit[8]uril (Q8) hosts is studied to modulate the supramolecular assembly process. Ring structure formation of the bivalent guest molecule with Q8 leads to enhanced binding properties and efficient inhibition of protein assemblies.

Graphical abstract: Cucurbit[8]uril templated supramolecular ring structure formation and protein assembly modulation

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Article information

DOI
https://doi.org/10.1039/C4CC08917K
Article type
Communication
Submitted
07 Nov 2014
Accepted
09 Jan 2015
First published
13 Jan 2015

Chem. Commun., 2015,51, 3147-3150

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Cucurbit[8]uril templated supramolecular ring structure formation and protein assembly modulation

M. Ramaekers, S. P. W. Wijnands, J. L. J. van Dongen, L. Brunsveld and P. Y. W. Dankers, Chem. Commun., 2015, 51, 3147 DOI: 10.1039/C4CC08917K

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