Issue 19, 2015
From the journal:

Chemical Communications

A metal-based tumour necrosis factor-alpha converting enzyme inhibitor†

Chung-Hang Leung,*a   Li-Juan Liu,a   Lihua Lu,b   Bingyong He,b   Daniel W. J. Kwong,b   Chun-Yuen Wong*c  and  Dik-Lung Ma*b  

* Corresponding authors

a State Key Laboratory of Quality Research in Chinese Medicine, Institute of Chinese Medical Sciences, University of Macau, Macao, China
E-mail: duncanleung@umac.mo

b Department of Chemistry, Hong Kong Baptist University, Kowloon Tong, Hong Kong, China
E-mail: edmondma@hkbu.edu.hk

c Department of Biology and Chemistry, City University of Hong Kong, Tat Chee Avenue, Kowloon, Hong Kong, China
E-mail: acywong@cityu.edu.hk

Abstract

We report herein a novel iridium(III) complex 1 as an antitumour necrosis factor agent and the first metal-based inhibitor of TACE enzymatic activity. Complex 1 inhibited TNF-α secretion and p38 phosphorylation in human monocytic THP-1 cells.

Graphical abstract: A metal-based tumour necrosis factor-alpha converting enzyme inhibitor

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Article information

DOI
https://doi.org/10.1039/C4CC09251A
Article type
Communication
Submitted
21 Nov 2014
Accepted
09 Jan 2015
First published
09 Jan 2015

Chem. Commun., 2015,51, 3973-3976

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A metal-based tumour necrosis factor-alpha converting enzyme inhibitor

C. Leung, L. Liu, L. Lu, B. He, D. W. J. Kwong, C. Wong and D. Ma, Chem. Commun., 2015, 51, 3973 DOI: 10.1039/C4CC09251A

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