Issue 10, 2015

Heterologous expression of highly reducing polyketide synthase involved in betaenone biosynthesis

Abstract

A unique highly reducing polyketide synthase (HR-PKS) with a reductase domain was identified in a betaenone biosynthetic gene cluster. Successful heterologous expression and characterization of the HR-PKS and trans-acting enoyl reductase (ER) provide insights into the core structure formation with a decalin scaffold and allow reconstitution of the betaenone biosynthetic machinery.

Graphical abstract: Heterologous expression of highly reducing polyketide synthase involved in betaenone biosynthesis

Supplementary files

Article information

Article type
Communication
Submitted
28 Nov 2014
Accepted
15 Dec 2014
First published
15 Dec 2014

Chem. Commun., 2015,51, 1878-1881

Author version available

Heterologous expression of highly reducing polyketide synthase involved in betaenone biosynthesis

T. Ugai, A. Minami, R. Fujii, M. Tanaka, H. Oguri, K. Gomi and H. Oikawa, Chem. Commun., 2015, 51, 1878 DOI: 10.1039/C4CC09512J

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