Issue 15, 2015

A novel aromatic carbocation-based coupling reagent for esterification and amidation reactions

Abstract

A novel tropylium-based coupling reagent has been developed to facilitate the synthesis of a series of esters, amides, lactones and peptides under mild reaction conditions. Remarkably, this reagent can be used in catalytic amounts in conjunction with a sacrificial reagent, offering a new and efficient method for nucleophilic coupling reactions of carboxylic acids.

Graphical abstract: A novel aromatic carbocation-based coupling reagent for esterification and amidation reactions

Supplementary files

Article information

Article type
Communication
Submitted
29 Nov 2014
Accepted
07 Jan 2015
First published
09 Jan 2015

Chem. Commun., 2015,51, 3131-3134

Author version available

A novel aromatic carbocation-based coupling reagent for esterification and amidation reactions

T. V. Nguyen and D. J. M. Lyons, Chem. Commun., 2015, 51, 3131 DOI: 10.1039/C4CC09539A

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