Issue 37, 2015

“Anion clamp” allows flexible protein to impose coordination geometry on metal ions

Abstract

X-ray crystal structures of human serum transferrin (77 kDa) with YbIII or FeIII bound to the C-lobe and malonate as the synergistic anion show that the large YbIII ion causes the expansion of the metal binding pocket while octahedral metal coordination geometry is preserved, an unusual geometry for a lanthanide ion.

Graphical abstract: “Anion clamp” allows flexible protein to impose coordination geometry on metal ions

Supplementary files

Article information

Article type
Communication
Submitted
02 Dec 2014
Accepted
27 Mar 2015
First published
27 Mar 2015

Chem. Commun., 2015,51, 7867-7870

“Anion clamp” allows flexible protein to impose coordination geometry on metal ions

M. Wang, T. P. Lai, L. Wang, H. Zhang, N. Yang, P. J. Sadler and H. Sun, Chem. Commun., 2015, 51, 7867 DOI: 10.1039/C4CC09642H

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